Vi modtog to abstracts fra den samme forskningsgruppegruppe. 
1) Cigarette smoking during pregnancy and hyperactive distractible offspring at 3.5 years: a follow-up study ved Karen Markussen Linnet et al
2) Giver stress i graviditeten opmærksomhedsforstyrrelser hos barnet? ved Carsten Obel et al. Karen Markussen Linnet kunne desværre ikke komme pga nærstående fødsel. Carsten Obel præsenterede derfor begge arbejder, og de to førsteforfattere delte førsteprisen på kr 4000,-
Her er de to abstracts:

Cigarette smoking during pregnancy and hyperactive distractible offspring at 3.5 years: a follow-up study.
Karen Markussen Linnet, 1, 2 Carsten Obel, 1 Else Bonde, 2 Per Hove Thomsen, 2 Niels Jørgen Secher, 1,4 Kirsten Wisborg 1 , Tine Brink Henriksen 1,3 .
1 Perinatal Epidemiological Research Unit, Dept. of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby, Denmark.
2 Psychiatric Hospital for Children & Adolescents, Aarhus University Hospital, Denmark.
3 Dept. of Paediatrics, Aarhus University Hospital, Skejby, Denmark.
4 Dept. of Obstetrics and Gynaecology, King Faisal Specialists Hospital and Research Centre, Riyadh, Saudi Arabia.

Background:
Animal studies and some human studies suggest that fetal nicotine exposure may result in symptoms related to Attention-Deficit Hyperactivity Disorders, but additional evidence is needed.

Methods: We performed a follow-up study of 1355 singletons born to Danish-speaking mothers. Information on smoking habits and other lifestyle factors was obtained from self-administered questionnaires during pregnancy. Approximately 3.5 years later, the parents provided information on their child's behaviour and based on the Behar scale, the children were categorised into three not mutually exclusive behaviour groups: hyperactive-distractible (13.6%), hostile-aggressive (4.6%), and anxious-fearful (6.4%) children.

Results:
Smoking in pregnancy increased the risk of hyperactive-distractible and anxious-fearful offspring. Compared with children of non-smokers, children of women who smoked 10 + cigarettes had a 60% increased risk of hyperactivity and distractibility (OR 1.6 95% CI 1.0-2.5; p<0.05) and a 70% increased risk of anxious-fearful behaviour (OR 1.7. 95% CI 0.9-3.2). The results were adjusted for caffeine and alcohol intake, socio-economic characteristics, parity, and gender. Additional adjustment for perinatal factors and parental psychopathology did not change the results substantially. Maternal smoking failed to influence hostile-aggressive behaviour in the offspring.

Conclusion:
Smoking 10 or more cigarettes during pregnancy is associated with an increased risk of hyperactive distractible behaviour in preschool children.

Giver stress i graviditeten opmærksomhedsforstyrrelser hos barnet?
Carsten Obel, Tine Brink Henriksen, Morten Hedegaard, Niels Bilenberg, Niels Jørgen Secher, Jørn Olsen
Email: co@soci.au.dk

Baggrund
Attention deficit hyperactivity disorder (ADHD) er en af de hyppigst forekommende diagnoser i børn- og ungdomspsykiatrien. Dyreforsøg tyder på at stress i graviditeten kan forårsage en adfærd hos afkommet, som kan minde om ADHD. En påvirkning af den føtale hjerne via den gravide mors hormonelle reaktion på stress er en biologisk mulighed, men der er sparsom evidens fra humane studier. Vi undersøgte sammenhængen mellem stress i graviditeten og ADHD relateret adfærd i den tidlige skolealder.

Materiale og metode
Vi fulgte 4031 dansk talende kvinder som gav oplysninger om stressfulde livsbegivenheder i første og andet trimester. Oplysninger om barnet blev indsamlet i 9-11 års alderen via spørgeskemaer til forældrene. Vi anvendte den danske ADHD problem score som bygger på Child Behaviour Checklist.

Resultater
Kvinder, som oplevede stressende livsbegivenheder i graviditeten havde større risiko for at få børn med høj ADHD score, mest udtalt blandt drenge. Jo flere stressende livsbegivenheder kvinden var udsat for midt i graviditeten des større var risikoen for at barnet havde en høj ADHD score (test for trend P< 0.01). Blandt piger fandt vi en høj ADHD problem score, hvis moderen havde oplevet flere livsbegivenheder både tidligt og midt i graviditeten.

Konklusion
Stress i graviditeten kan muligvis påvirke den føtale hjerneudvikling